Captopril Dosage & Administration

Captopril dosing must be individualised to the patient's condition, weight, kidney and liver function, and other medications. Most ACE inhibitors are dosed once or twice daily. Start at low doses and titrate upward based on blood pressure response and tolerability. Take at the same time each day.

Common Dosing Contexts

→Hypertension: start low, titrate over weeks to target BP
→Heart failure: start very low, titrate slowly to target dose
→Diabetic nephropathy: aim to maximise dose within tolerance
→Post-MI: start within 24 hours if stable

Dosage Safety Notes

→Check renal function and potassium before starting and after dose changes
→Hold dose if patient is dehydrated (e.g., vomiting, diarrhoea, before surgery)
→First dose may cause hypotension — consider first dose at bedtime

How to Take

→Captopril is available in the following formulations depending on the indication.
→Always follow the exact dose and frequency prescribed by your healthcare provider.
→Do not adjust your dose without consulting your doctor or pharmacist.

Safety Note

Do not exceed the prescribed dose of Captopril. If you miss a dose, follow the specific guidance provided with your prescription — generally take it as soon as you remember unless it is nearly time for the next dose.

Frequently Asked Questions

Can I take a higher dose of Captopril if my symptoms don't improve?

No. Never increase the dose of Captopril without medical advice. If your current dose is insufficient, contact your healthcare provider to discuss a dose adjustment or alternative treatment.

Why does the ACE inhibitor cause a cough?

ACE inhibitors prevent the breakdown of bradykinin, which accumulates in the airways causing irritation and a dry, persistent cough. This affects 10–15% of patients. If troublesome, switching to an ARB typically resolves the cough.

More About Captopril

Side Effects

Drug Interactions

Warnings & Precautions

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.