Amlodipine Dosage & Administration

Amlodipine dosing must be individualised to the patient's condition, weight, kidney and liver function, and other medications. Most CCBs are taken once daily. Modified-release formulations provide smoother blood pressure control. Doses are titrated based on blood pressure or heart rate response.

Common Dosing Contexts

→Hypertension: once daily dosing, often as add-on to other antihypertensives
→Angina: dose adjusted to reduce exercise-induced symptoms
→Rate control in AF: dose titrated to target heart rate

Dosage Safety Notes

→Do not crush or chew modified-release tablets
→Avoid grapefruit juice (inhibits CYP3A4, increases drug levels)
→Do not combine verapamil or diltiazem with beta blockers (heart block risk)

How to Take

→Amlodipine is available in the following formulations depending on the indication.
→Always follow the exact dose and frequency prescribed by your healthcare provider.
→Do not adjust your dose without consulting your doctor or pharmacist.

Safety Note

Do not exceed the prescribed dose of Amlodipine. If you miss a dose, follow the specific guidance provided with your prescription — generally take it as soon as you remember unless it is nearly time for the next dose.

Frequently Asked Questions

Can I take a higher dose of Amlodipine if my symptoms don't improve?

No. Never increase the dose of Amlodipine without medical advice. If your current dose is insufficient, contact your healthcare provider to discuss a dose adjustment or alternative treatment.

Why do CCBs cause ankle swelling?

Dihydropyridine CCBs dilate arteries more than veins. The resulting increased capillary pressure causes fluid to leak into tissues, particularly in dependent areas like the ankles. This is a pharmacological effect, not a sign of heart failure, though it can be uncomfortable.

More About Amlodipine

Side Effects

Drug Interactions

Warnings & Precautions

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.