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VHOSPITAL.CLINIC · Drug Reference

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Valacyclovir Side Effects

Like all medications, Valacyclovir can cause side effects. Most people do not experience serious adverse effects, but it is important to know what to look for and when to seek medical care.

Common Side Effects

  • Nausea and GI discomfort
  • Headache
  • Fatigue
  • Renal effects (acyclovir — adequate hydration required)

Serious Side Effects

  • Renal toxicity (acyclovir, tenofovir)
  • Neurological effects (high-dose acyclovir)
  • Bone marrow suppression (ganciclovir)
  • Severe skin reactions

When to Seek Medical Care

  • Significant decrease in urine output
  • Severe headache, confusion, or seizures
  • Unusual bruising or pallor

Safety Note

If you experience any unexpected or concerning symptoms while taking Valacyclovir, contact your doctor or pharmacist. Do not stop taking Valacyclovir without medical advice unless you experience a serious adverse reaction.

Frequently Asked Questions

Are side effects from Valacyclovir common?

Most patients tolerate Valacyclovir well at therapeutic doses. Common side effects are usually mild and often improve after the first few weeks. Serious side effects are less common but should be reported immediately.

What should I do if I experience side effects from Valacyclovir?

Mild side effects: discuss with your pharmacist, as many resolve spontaneously. Serious side effects: seek medical care immediately and contact your prescriber. Do not stop Valacyclovir abruptly for long-term conditions without medical advice.

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.