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VHOSPITAL.CLINIC · Drug Reference

DiureticPrescription Only

Spironolactone Dosage & Administration

Spironolactone dosing must be individualised to the patient's condition, weight, kidney and liver function, and other medications. Dosing depends on diuretic class and indication. Loop diuretics are the most potent; thiazides are preferred for hypertension. Take in the morning to avoid nocturia.

Common Dosing Contexts

  • Hypertension: low-dose thiazide, once daily in morning
  • Heart failure: loop diuretic, adjusted to fluid balance
  • Oedema: dose titrated to response and tolerability

Dosage Safety Notes

  • Take in the morning to minimise nocturia
  • Monitor weight daily in heart failure to detect fluid retention
  • Ensure adequate fluid intake to prevent dehydration

How to Take

  • Spironolactone is available in the following formulations depending on the indication.
  • Always follow the exact dose and frequency prescribed by your healthcare provider.
  • Do not adjust your dose without consulting your doctor or pharmacist.

Safety Note

Do not exceed the prescribed dose of Spironolactone. If you miss a dose, follow the specific guidance provided with your prescription — generally take it as soon as you remember unless it is nearly time for the next dose.

Frequently Asked Questions

Can I take a higher dose of Spironolactone if my symptoms don't improve?

No. Never increase the dose of Spironolactone without medical advice. If your current dose is insufficient, contact your healthcare provider to discuss a dose adjustment or alternative treatment.

Why should I take my diuretic in the morning?

Diuretics increase urine production for several hours after taking them. Taking them in the morning allows this effect to occur during the day rather than disrupting sleep with nocturia (frequent nighttime urination).

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.