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VHOSPITAL.CLINIC · Drug Reference

Non-Opioid AnalgesicAvailable OTC

Nefopam Side Effects

Like all medications, Nefopam can cause side effects. Most people do not experience serious adverse effects, but it is important to know what to look for and when to seek medical care.

Common Side Effects

  • Generally very well tolerated at recommended doses
  • Rare nausea or stomach discomfort
  • Skin rash (uncommon)

Serious Side Effects

  • Hepatotoxicity with overdose (paracetamol)
  • Severe skin reactions (rare)
  • Haematological effects (metamizole — agranulocytosis)

When to Seek Medical Care

  • Yellowing of skin or eyes (jaundice)
  • Dark urine or pale stools
  • Signs of severe allergic reaction
  • Persistent high fever not responding to treatment

Safety Note

If you experience any unexpected or concerning symptoms while taking Nefopam, contact your doctor or pharmacist. Do not stop taking Nefopam without medical advice unless you experience a serious adverse reaction.

Frequently Asked Questions

Are side effects from Nefopam common?

Most patients tolerate Nefopam well at therapeutic doses. Common side effects are usually mild and often improve after the first few weeks. Serious side effects are less common but should be reported immediately.

What should I do if I experience side effects from Nefopam?

Mild side effects: discuss with your pharmacist, as many resolve spontaneously. Serious side effects: seek medical care immediately and contact your prescriber. Do not stop Nefopam abruptly for long-term conditions without medical advice.

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.