Indomethacin Drug Interactions

NSAIDs interact with a broad range of medications by affecting platelet function, renal blood flow, and metabolic pathways. Always inform your prescriber of all medications including OTC drugs.

Key Drug Interactions

→Anticoagulants (warfarin, rivaroxaban): greatly increased bleeding risk
→Aspirin: reduced cardioprotective effect of aspirin; combined GI risk
→ACE inhibitors / ARBs: reduced antihypertensive efficacy; nephrotoxicity
→Diuretics: reduced diuretic effect; risk of acute kidney injury
→Lithium: NSAIDs can raise lithium levels, risk of toxicity
→Methotrexate: NSAIDs can increase methotrexate toxicity
→SSRIs / SNRIs: increased risk of GI bleeding when combined
→Corticosteroids: additive gastrointestinal risk

Alcohol Interactions

→Alcohol significantly increases the risk of stomach bleeding and ulceration when combined with NSAIDs. Avoid alcohol during treatment.

Supplement and Food Interactions

→Fish oil and vitamin E supplements may further increase bleeding risk. Ginkgo biloba has antiplatelet effects and should be avoided.

Safety Note

Always tell your doctor and pharmacist about all prescription medicines, non-prescription medicines, vitamins, and herbal or dietary supplements before starting Indomethacin. Keep an up-to-date medicines list to share with all healthcare providers.

Frequently Asked Questions

Can I take Indomethacin with common over-the-counter medicines?

Some OTC medications interact with Indomethacin. NSAIDs, aspirin, antihistamines, antacids, and herbal products can all have interactions. Ask your pharmacist to check for interactions before taking any new OTC product.

Can I drink alcohol while taking Indomethacin?

Alcohol significantly increases the risk of stomach bleeding and ulceration when combined with NSAIDs. Avoid alcohol during treatment.

More About Indomethacin

Dosage & Administration

Side Effects

Warnings & Precautions

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.