Hydrochlorothiazide Drug Interactions

Diuretics interact with agents affecting blood pressure, renal function, and electrolyte balance.

Key Drug Interactions

→ACE inhibitors / ARBs: increased hypotension risk and hyperkalaemia (with K-sparing)
→NSAIDs: reduced diuretic efficacy; acute kidney injury risk
→Digoxin: hypokalaemia increases digoxin toxicity
→Lithium: thiazides reduce lithium clearance — toxicity risk
→Antidiabetics: thiazides may worsen glycaemia

Alcohol Interactions

→Alcohol can enhance the blood pressure-lowering effect of diuretics, increasing dizziness and fainting risk. Limit alcohol intake.

Supplement and Food Interactions

→Potassium supplements or salt substitutes with K-sparing diuretics: risk of dangerous hyperkalaemia. Magnesium supplementation may be needed with loop diuretics.

Safety Note

Always tell your doctor and pharmacist about all prescription medicines, non-prescription medicines, vitamins, and herbal or dietary supplements before starting Hydrochlorothiazide. Keep an up-to-date medicines list to share with all healthcare providers.

Frequently Asked Questions

Can I take Hydrochlorothiazide with common over-the-counter medicines?

Some OTC medications interact with Hydrochlorothiazide. NSAIDs, aspirin, antihistamines, antacids, and herbal products can all have interactions. Ask your pharmacist to check for interactions before taking any new OTC product.

Can I drink alcohol while taking Hydrochlorothiazide?

Alcohol can enhance the blood pressure-lowering effect of diuretics, increasing dizziness and fainting risk. Limit alcohol intake.

More About Hydrochlorothiazide

Dosage & Administration

Side Effects

Warnings & Precautions

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.