Fluoxetine Drug Interactions

SSRIs interact significantly with other serotonergic drugs and blood-thinning agents.

Key Drug Interactions

→MAOIs: contraindicated — serotonin syndrome, potentially fatal (14-day washout required)
→Tramadol / triptans: increased serotonin syndrome risk
→NSAIDs / aspirin / anticoagulants: increased bleeding risk (reduced platelet aggregation)
→Lithium: additive serotonergic effects
→Tamoxifen: some SSRIs inhibit CYP2D6, reducing tamoxifen efficacy
→Alcohol: increased CNS depression and worsened depression

Alcohol Interactions

→Alcohol and SSRIs both affect the CNS. Alcohol can worsen depression and anxiety symptoms. While not absolutely contraindicated, it is best to avoid alcohol during treatment.

Supplement and Food Interactions

→St John's Wort is contraindicated — increases serotonin syndrome risk significantly. 5-HTP and tryptophan supplements also increase serotonin and should be avoided.

Safety Note

Always tell your doctor and pharmacist about all prescription medicines, non-prescription medicines, vitamins, and herbal or dietary supplements before starting Fluoxetine. Keep an up-to-date medicines list to share with all healthcare providers.

Frequently Asked Questions

Can I take Fluoxetine with common over-the-counter medicines?

Some OTC medications interact with Fluoxetine. NSAIDs, aspirin, antihistamines, antacids, and herbal products can all have interactions. Ask your pharmacist to check for interactions before taking any new OTC product.

Can I drink alcohol while taking Fluoxetine?

Alcohol and SSRIs both affect the CNS. Alcohol can worsen depression and anxiety symptoms. While not absolutely contraindicated, it is best to avoid alcohol during treatment.

More About Fluoxetine

Dosage & Administration

Side Effects

Warnings & Precautions

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.