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VHOSPITAL.CLINIC · Drug Reference

AntifungalAvailable OTC

Fluconazole Side Effects

Like all medications, Fluconazole can cause side effects. Most people do not experience serious adverse effects, but it is important to know what to look for and when to seek medical care.

Common Side Effects

  • Topical: local irritation or burning
  • Oral: nausea, abdominal discomfort
  • Headache (systemic)

Serious Side Effects

  • Hepatotoxicity (systemic azoles)
  • QT prolongation (azoles)
  • Drug interactions via CYP450 enzymes
  • Nephrotoxicity (amphotericin B)

When to Seek Medical Care

  • Jaundice or dark urine during systemic treatment
  • Heart palpitations
  • Severe skin reactions

Safety Note

If you experience any unexpected or concerning symptoms while taking Fluconazole, contact your doctor or pharmacist. Do not stop taking Fluconazole without medical advice unless you experience a serious adverse reaction.

Frequently Asked Questions

Are side effects from Fluconazole common?

Most patients tolerate Fluconazole well at therapeutic doses. Common side effects are usually mild and often improve after the first few weeks. Serious side effects are less common but should be reported immediately.

What should I do if I experience side effects from Fluconazole?

Mild side effects: discuss with your pharmacist, as many resolve spontaneously. Serious side effects: seek medical care immediately and contact your prescriber. Do not stop Fluconazole abruptly for long-term conditions without medical advice.

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or pharmacist before changing your medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information.