Cold Intolerance: Clinical Meaning

Hypothyroidism

Hypothyroidism occurs when the thyroid gland doesn't produce enough thyroid hormone. This slows metabolism and causes fatigue, weight gain, cold intolerance, constipation, and depression. Hashimoto's thyroiditis is the most common cause.

Vitamin D Deficiency

Vitamin D deficiency impairs calcium absorption and bone mineralization, causing bone pain, muscle weakness, fatigue, and increased fracture risk. It is extremely common globally due to limited sun exposure and dietary insufficiency.

Iodine Deficiency

Iodine deficiency is the leading preventable cause of intellectual disability worldwide. The thyroid requires iodine to produce hormones; deficiency leads to hypothyroidism and goiter.