How Is Antiphospholipid Syndrome Diagnosed? Tests, Criteria & Process
Antiphospholipid Syndrome diagnosis relies on Full blood count (FBC), Comprehensive metabolic panel (electrolytes, creatinine, LFTs), Urinalysis. Learn the full diagnostic pathway, clinical criteria, differential workup, and what to expect at your evaluation.
Updated March 27, 2026
Antiphospholipid Syndrome is diagnosed using Full blood count (FBC), Comprehensive metabolic panel (electrolytes, creatinine, LFTs), Urinalysis and targeted clinical evaluation. Antiphospholipid syndrome is an autoimmune disorder causing abnormal blood clotting, leading to deep vein thrombosis, pulmonary embolism, strokes, and recurrent miscarriages. Lifelong anticoagulation is the primary treatment.
Clinical Context
The diagnostic process for Antiphospholipid Syndrome begins with Thorough history and physical examination followed by basic blood and urine tests; targeted specialist investigation as needed. Key investigations include Full blood count (FBC), Comprehensive metabolic panel (electrolytes, creatinine, LFTs), Urinalysis, Chest X-ray. The gold standard is: Directed investigation based on clinical history and physical examination findings. Clinical guidelines from NICE / BMJ Best Practice / WHO define the diagnostic criteria and recommended investigation pathway.
Clinical Pathway
Antiphospholipid Syndrome — Full Condition GuideCondition HubAntiphospholipid Syndrome — Differential DiagnosisDifferentialAntiphospholipid Syndrome — Treatment PathwaysTreatmentAntiphospholipid Syndrome — Prognosis & OutlookPrognosisFrequently Asked Questions
How Is Antiphospholipid Syndrome Diagnosed? Tests, Criteria & Process?+
Antiphospholipid Syndrome is diagnosed using Full blood count (FBC), Comprehensive metabolic panel (electrolytes, creatinine, LFTs), Urinalysis and targeted clinical evaluation. Antiphospholipid syndrome is an autoimmune disorder causing abnormal blood clotting, leading to deep vein thrombosis, pulmonary embolism, strokes, and recurrent miscarriages. Lifelong anticoagulation is the primary treatment.
How do doctors test for antiphospholipid syndrome?+
The main tests used to diagnose Antiphospholipid Syndrome include Full blood count (FBC), Comprehensive metabolic panel (electrolytes, creatinine, LFTs), Urinalysis. Your doctor will select investigations based on your symptoms, clinical findings, and risk factors.
How long does it take to diagnose Antiphospholipid Syndrome?+
The time to diagnosis varies. Some cases are identified within hours using clinical presentation and blood tests; others require weeks, repeated investigations, or specialist referral.
Can Antiphospholipid Syndrome be missed on initial testing?+
Yes — Antiphospholipid Syndrome can be missed if initial tests are negative or if the presentation is atypical. If clinical suspicion remains high, repeat testing or specialist referral is appropriate.
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