VHOSPITAL.CLINIC · Health Guide

Food Allergies vs Food Intolerance: Key Differences

Understanding true food allergies, food intolerances, and how to manage both safely.

Food allergies involve an immune system reaction and can be life-threatening. Food intolerances are digestive responses that cause discomfort but are not immune-mediated. The distinction is critical for management.

The most common allergens include peanuts, tree nuts, milk, eggs, wheat, soy, fish, and shellfish. Reactions range from mild hives to severe anaphylaxis.

Diagnosis uses medical history, skin prick testing, specific IgE blood tests, and oral food challenges. Confirmed allergy requires strict avoidance and epinephrine auto-injectors.

Oral immunotherapy is now available for peanut, milk, and egg allergies and can significantly increase tolerance threshold.

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Possible Causes

  • Infections and inflammation — bacterial, viral, or autoimmune triggers activate abdominal pain
  • Metabolic disturbances — hormonal imbalances, nutrient deficiencies, or blood sugar changes
  • Structural or vascular causes — tissue damage, nerve compression, or circulatory problems
  • Psychological factors — stress, anxiety, and depression can produce measurable physical abdominal pain

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Medical ReviewvHospital Editorial Team · 2024–2025
Sources:WHOPubMedUpToDateNICE