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VHOSPITAL.CLINIC · Drug Reference

Non-Benzodiazepine HypnoticPrescription Only

Zaleplon

Zaleplon is a benzodiazepine that enhances GABA activity to produce anxiolytic, sedative, muscle relaxant, and anticonvulsant effects.

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Overview

Benzodiazepines enhance the effect of GABA at the GABA-A receptor, producing sedative, anxiolytic, muscle-relaxant, and anticonvulsant effects. They are effective but carry significant risks of dependence with prolonged use.

What Zaleplon Is Used For

Used short-term for acute anxiety, panic attacks, acute seizures, alcohol withdrawal, procedural sedation, and insomnia. Not recommended for long-term use due to dependence risk.

Safety Summary

Use for the shortest possible duration. Do not stop abruptly after regular use. Do not combine with other CNS depressants including alcohol.

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or qualified health provider before starting, stopping, or changing any medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information, UpToDate.