VHOSPITAL.CLINIC · Antiparasitic Treatment
Mebendazole is highly effective for enterobiasis (pinworm infection), with a single 100 mg dose achieving >90% eradication of Enterobius vermicularis.
Mebendazole binds selectively to β-tubulin in parasitic nematodes, preventing polymerisation into microtubules. This blocks glucose uptake and disrupts cellular transport in the worm, causing death from energy depletion.
Single dose of 100 mg, repeated after 2 weeks. Treat all household members simultaneously. Chewable tablet can be chewed or swallowed. Not significantly absorbed — acts locally in the gut.
This is a general reference. Always follow your physician's prescription and current treatment guidelines.
Mebendazole kills adult worms but not eggs. Pinworm eggs hatch within 2 weeks. The repeat dose at day 14 eliminates the next generation before they can reproduce, breaking the reinfection cycle.
Yes. WHO guidelines recommend simultaneous treatment of all household members regardless of symptoms. Enterobius eggs survive on surfaces for up to 3 weeks and are easily transmitted within households.
Mebendazole is not recommended in the first trimester. In the second and third trimester, single-dose treatment is generally considered acceptable when the risk of infection outweighs the theoretical risk to the foetus.
By treating Enterobiasis (Pinworm Infection), Mebendazole addresses these associated symptoms:
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