VHOSPITAL.CLINIC · Antiparasitic Treatment
Mebendazole 500 mg as a single dose is an effective WHO-approved treatment for ascariasis, with a 3-day course offering higher cure rates for heavy infections.
Mebendazole selectively binds Ascaris β-tubulin with high affinity, blocking glucose uptake and microtubule formation. The drug acts locally in the gut with minimal systemic absorption, reducing side effects.
Single dose: 500 mg once. Three-day course: 100 mg twice daily for 3 days (higher cure rates for heavy burden). Children over 2 years: same adult dose. Take with or without food.
This is a general reference. Always follow your physician's prescription and current treatment guidelines.
For heavy Ascaris infections (many eggs on stool microscopy, abdominal symptoms, malnutrition), a 3-day mebendazole course (100 mg twice daily) achieves higher cure rates than a single dose.
They should not be given simultaneously as they have the same mechanism. If one fails, the other can be tried as retreatment after 2–4 weeks. Combination therapy offers no advantage.
Follow-up stool microscopy 2–4 weeks after treatment confirms clearance. Cure is defined as absence of eggs. In children, weight gain and improved appetite are practical clinical indicators.
By treating Ascariasis, Mebendazole addresses these associated symptoms:
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