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VHOSPITAL.CLINIC · Drug Reference

AntipsychoticPrescription Only

Clozapine

Clozapine is an antipsychotic used to manage schizophrenia, bipolar disorder, and acute psychosis by modulating dopamine and serotonin neurotransmission.

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Overview

Antipsychotics primarily block dopamine D2 receptors, reducing positive symptoms of psychosis (hallucinations, delusions). Atypical antipsychotics also affect serotonin receptors, providing better tolerability and activity against negative symptoms.

What Clozapine Is Used For

Used in schizophrenia, bipolar disorder (manic episodes), and short-term treatment of severe agitation. Some are used for augmentation in treatment-resistant depression.

Safety Summary

Do not stop without medical supervision. Report any involuntary movements. Regular metabolic monitoring (weight, glucose, lipids) is essential with atypical antipsychotics.

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Medical Disclaimer: This drug reference is provided for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or qualified health provider before starting, stopping, or changing any medication. Information reviewed by the vHospital Editorial Team · Sources: WHO, BNF, FDA prescribing information, UpToDate.