Hereditary Angioedema

Hereditary angioedema is a rare genetic disorder causing recurrent episodes of severe swelling in the skin, GI tract, and airways due to C1-inhibitor deficiency. Laryngeal attacks can be fatal; specific treatments (icatibant, C1-INH concentrate) are available.

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Common Symptoms

Facial swelling Throat tightness Abdominal pain Swelling

Possible Causes

Genetic and hereditary factors
Environmental exposures or lifestyle factors
Infections or immune system dysfunction
Chronic stress or nutritional deficiencies

Risk Factors

Family history of the condition
Age and sex-related predisposition
Pre-existing chronic conditions
Lifestyle factors (diet, physical activity, smoking)

When to Seek Medical Help

Symptoms are sudden, severe, or rapidly worsening
Symptoms persist for more than 1–2 weeks without improvement
Symptoms significantly affect daily activities or sleep
You experience chest pain, difficulty breathing, or loss of consciousness

Related Symptoms

Hereditary Angioedema is commonly associated with the following symptoms:

Facial swelling Throat tightness Abdominal pain Swelling

Medical References

Content on this page is informed by evidence-based clinical sources including:

World Health Organization (WHO)Global health guidance and disease classification
National Health Service (NHS)UK clinical guidelines and patient information
National Institute for Health and Care Excellence (NICE)Evidence-based clinical practice guidelines
Centers for Disease Control and Prevention (CDC)US public health data and clinical recommendations
PubMed – NCBIPeer-reviewed biomedical literature and clinical studies
Cochrane LibrarySystematic reviews and meta-analyses in evidence-based medicine

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